Interferons and Cancer
نویسندگان
چکیده
منابع مشابه
Interferons
nterferons, naturally occuring glycoproteins with molecular weights of approximately 20,000 daltons, possess antiviral, antiproliferative, and immune-stimulating properties. They are classified into 3 antigenically distinct forms that are derived from different cell types. Alpha (or) interferons are derived from leukocytes, beta ([3) interferons from fibroblasts, and gamma (/) interferons from ...
متن کاملType I Interferons and Natural Killer Cell Regulation in Cancer
Type I interferons (IFNs) are known to mediate antitumor effects against several tumor types and have therefore been commonly used in clinical anticancer treatment. However, how IFN signaling exerts its beneficial effects is only partially understood. The clinically relevant activity of type I IFNs has been mainly attributed to their role in tumor immune surveillance. Different mechanisms have ...
متن کاملInterferons and microRNAs.
Plants rely heavily on an adaptive RNA degradation system mediated by an RNA interference mechanism to combat viral infection, whereas mammals fight infection with specific antibodies and lymphocytes that are adapted to specific viral antigens, and also employ nonadaptive defenses, such as production of interferons (IFNs) that block viral replication and stimulate the host immune response. Ther...
متن کاملInterferons in hematopoiesis and leukemia
Interferons not only exert a fundamental role during inflammation and immune responses but also modulate the activity of hematopoietic stem cells during homeostatic and demand-adapted hematopoiesis. Identical mechanisms regulate the homeostasis and proliferation of leukemic stem cells (LSCs). Understanding these mechanisms may lead to novel therapeutic approaches against leukemia.
متن کاملType 1 interferons and myositis
Recent studies suggest a mechanistic role for molecules induced by type 1 interferons in the pathogenesis of some forms of myositis. For dermatomyositis, evidence that these molecules injure myofibers seems especially strong. In the group of disorders known as polymyositis, the study of blood samples suggests a potential role. It is unknown what drives the sustained presence of type 1 interfero...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 1978
ISSN: 1460-2105,0027-8874
DOI: 10.1093/jnci/60.6.1191